The eukaryotes sterol pathways are extremely conserved and these biosynthetic pathway are very long which includes the synthesis of dolichols, coenzyme Q, heme A, and isoprenylated proteins.14-Demethylase is an essential enzyme of the cytochrome P450 superfamily, which is potential the target of azole antifungals. Predicted results shows that 14-alpha sterol demethylase have molecular weight of 58930.8 Daltons and the theoretical isoelectric point (pI) of 7.64. The negative Grand average of hydropathicity (GRAVY) index of ‐0.125. The Aliphatic index of Aspergillus fumigates 14-alpha sterol demethylase is 89.48. Alpha helix (Hh) accounts 210 amino acids of about 40.08%. The extended strand (Ee) had 91 amino acids accounting 17.37, Beta turn (Tt) made up of 51 amino acids making up 9.73% and random coil (Cc) made up of 172 amino acids accounting 32.82%. The subcellular localization of 14alpha sterol demethylase Cyp51B was predicted to be a Plasma membrane protein.
Hair loss is very common disorders in human belonging to every age group . Hair loss (alopecia) affects men and women and often significantly affects social and psychologic well-being. Although alopecia has several causes, a careful history, close attention to the appearance of the hair loss, and a few simple studies can quickly narrow the potential diagnoses. Androgenetic alopecia, one of the most common forms of hair loss, usually has a specific pattern of temporal-frontal loss in men and central thinning in women. Topical minoxidil has approved to treat men and women, with the addition of finasteride for men. Telogen effluvium is characterized by the loss of “handfuls” of hair, often following emotional or physical stress. Alopecia areata, trichotillomania, traction alopecia, and tinea capitis have unique features on microscopic examination that aid in diagnosis. Evaluating and treating hair loss (alopecia) is an important part of primary care, yet many physicians find it complex and confusing. Hair loss affects men and women and frequently has significant social and psychologic consequences. Therefore it is highly imperative to find safe alternative or a new therapy to treat such hair losses. RCHMA has developed a new homoeopathic formulation to treat all kind of hair disorders. Formulation “HAIR LOSS” is highly efficient to treat various disorders. About more than 4000 diagnosed cases of hair loss are well treated. Some cases were detailed in the present paper.A detail review of its efficiencies are explored in the paper for general as well as scientific interest.
Present paper reports a case of fungal prostatitis which has perfectly been cured with homoeopathic drugs. Diagnosis is based on fungal culture of prostate fluid before and after treatment. Present case added to literature, suggesting that clinicians need to consider fungal infections in patients who fail standard therapy for prostatitis, either as a primary causative organism or as secondary agents induced by broad-spectrum antibiotic use. Homeopathic drugs are potentially alternative to treat fungal prostatitis.